Innovations in Combination Therapy to Dominate COPD Treatment Market
The chronic obstructive pulmonary disease treatment market is projected to be valued at ~US$ 26.2 billion in the year 2027. The high prevalence of chronic obstructive pulmonary disease (COPD) and the need for improved treatment options are catalyzing market growth.
To meet the needs of patients, healthcare companies in the COPD treatment market are developing efficacious treatment options in combination therapy. Revenue of combination therapy was valued at ~US$ 9.6 billion in 2018; the highest amongst all the drug classes in the chronic obstructive pulmonary disease treatment market.
With increased research & development, healthcare companies are innovating new triple combination therapies. For instance, in June 2019, AstraZeneca — an English-Swedish multinational pharmaceutical company, announced the approval of Breztri Aerosphere — a pressurized metered dose inhaler with built-in triple combination therapy for patients suffering from moderate to severe COPD in Japan. Stakeholders in the chronic obstructive pulmonary disease treatment market are running continuous clinical trials to meet the primary endpoints of the disease.
Dual and Triple Therapies Minimize Moderate and Severe Exacerbations
With ongoing developments in the chronic obstructive pulmonary disease treatment market, healthcare companies are weighing the responses and combination of therapies in patients. As such, there is a strife between the credibility of dual combination therapy and long acting bronchodilators for treatment in COPD patients.
To achieve greater effectiveness of therapies in the chronic obstructive pulmonary disease treatment market, manufacturers have integrated combinations of bronchodilators to treat patients with moderate to severe COPD. This includes the combination of long acting beta agonist (LABA) with long acting muscarinic antagonist (LAMA). Thus, the LAMA and LABA group of inhalers are considered safe and effective in COPD patients.
Also, triple therapy has shown better outcome in patients as compared to single-agent LAMA monotherapy in the COPD treatment market. Compared with LAMA monotherapy, triple therapy helps to drastically reduce moderate or severe exacerbations. Thus, healthcare companies are making significant improvements to enhance triple therapy against dual therapy LABA/LAMA.
Improved Bronchodilators Reduce Reversibility in Patients
Stakeholders in the chronic obstructive pulmonary disease treatment landscape are developing methods to reduce emphysema and the mortality rates of patients. This has instigated the need for combined bronchodilator response (BDR) in patients. Revenue of bronchodilators in the COPD treatment market is estimated to reach a value of ~US$ 5.5 billion by 2027; the second-highest amongst all drug classes. This is why, healthcare professionals are taking regular follow-ups on patients with combined-BDR. However, the results in combined-BDR are associated with greater frequency of exacerbations and symptoms of asthma. Thus, healthcare companies are increasing research to identify patients with asthma-COPD overlaps, and developing treatment alternatives that result in improved outcomes.
Studies published in the European Respiratory Journal stated that, bronchodilator reversibility might not distinguish asthma from COPD. It was also found that, the prevalence of bronchodilator reversibility was higher in patients with COPD than in asthma patients. Thus, with the help of bronchodilator response testing, healthcare companies are developing improved prebronchodilators that minimize the adverse effects in patients.
chronic obstructive pulmonary disease treatment market segmentation
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Analysts’ Viewpoint on COPD Treatment Market
The chronic obstructive pulmonary disease treatment market is anticipated for high growth during the forecast period. Although retail pharmacies dominate more than half of the market share, online pharmacies are expected to experience steady growth in the market. Healthcare companies are introducing digital inhalers with built-in sensors for patients suffering from COPD. For instance, in December 2018, Teva Pharmaceutical Industries — a leading Israeli multinational pharmaceutical company, announced the launch of ProAir® Digihaler™ — a digital inhaler with Bluetooth wireless technology for patients with asthma and COPD. However, healthcare companies are developing improved therapies to reduce the reversibility of inhalers in patients. Thus, manufacturers should focus on increasing triple therapy treatment options to effectively minimize exacerbations.
Chronic Obstructive Pulmonary Disease (COPD) Treatment Market: Overview
The chronic obstructive pulmonary disease (COPD) treatment market for the historical period of 2017-2018 and forecast period of 2019-2027, increasing burden of chronic obstructive pulmonary disease, rise in geriatric population, and surge in product approvals and launches are expected to boost the global chronic obstructive pulmonary disease treatment market during the forecast period.
According to the report, the global chronic obstructive pulmonary disease treatment market was valued at ~US$ 17.4 Bn in 2018. The COPD treatment market is expected to expand at a CAGR of ~5% from 2019 to 2027.
Increase in Prevalence of Chronic Obstructive Pulmonary Disease: A Key Driver of COPD Treatment Market
Chronic Obstructive Pulmonary Disease (COPD) is a major health concern affecting a large number of people across the globe. The disease burden is rising, thereby increasing the need for COPD management, and this is anticipated to drive the global chronic obstructive pulmonary disease treatment market.
Tobacco smoking could also lead to COPD, as such, boosting the COPD treatment market. The number of adults addicted to smoking has been increasing. Other risk factors include occupation and indoor air pollution. According to the WHO, the primary cause of COPD is exposure to tobacco smoke (either active smoking or passive smoking).
According to an article published by Medscape in April 2019, the prevalence of COPD, worldwide, varies between 7 - 19%. The Burden of Obstructive Lung Disease (BOLD) study found a global prevalence of 10.1%. Men have a pooled prevalence of 11.8%, while it has a prevalence of 8.5% in women. The numbers vary across different regions around the world. Cape Town, South Africa, has the highest prevalence, affecting 22.2% of men and 16.7% of women.
According to a report by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) published in 2018, the prevalence and burden of COPD are projected to increase in the near future, due to continued exposure to COPD risk factors and aging of the world’s population, which is thereby boosting the growth of the chronic obstructive pulmonary disease treatment market.
Increase in Adoption of Combination Therapy: A Key Driver of COPD Treatment Market
Combination therapy includes LAMA-ICS, LABA-ICS, triple therapy, and other combination drugs, which are anticipated to drive the chronic obstructive pulmonary disease treatment market.
The adoption of combination therapy is increasing, as it is more effective than separate use of bronchodilator and corticosteroid. There has been an increase in the number of patients being successfully treated with combination therapy, who were not showing signs of recovery with bronchodilators or corticosteroids treatments, which is thereby boosting the growth of the COPD treatment market.
Combination therapy is more effective than monotherapy for improving the symptoms and quality of life.
Regulatory authorities such as the FDA, the European Commission, and the Ministry of Health, Labour and Welfare (MHLW), which is a cabinet level ministry of the Japanese government, have approved the use of combination drugs for the treatment of COPD. In November 2018, GlaxoSmithKline plc and Innoviva, Inc. received authorization from the European Commission for the expanded use of once-daily Trelegy Ellipta, the first single inhaler triple therapy indicated for COPD patients who were not adequately treated with dual bronchodilation. These drugs have a longer patent cover, i.e., till 2030, which will lead to high valuation of the chronic obstructive pulmonary disease treatment market.
In April 2019, the FDA approved the combination therapy for COPD maintenance. A fixed-dose combination of long-acting muscarinic antagonist (LAMA) aclidinium bromide (400 mcg) and long-acting beta-agonist (LABA) formoterol fumarate (12 mcg) has been approved by the FDA for the maintenance and treatment of chronic obstructive pulmonary disease.
Increase in the success rate of combination therapy for COPD treatment and recent regulatory approvals have propelled the adoption of combination therapy in COPD management, thereby boosting the growth of the COPD treatment market.
Patent Expiry of Branded Products and Availability of Generic Equivalents Hamper Market
Patents prevent other manufacturers from developing drugs that are being exclusively manufactured by a patent holder. The patent expiry of branded drugs has a significant impact on the pharmaceutical industry.
In case of the COPD treatment market, a few of the players face the threat of patient expiry, which further increases the availability of generic versions of drugs and creates pricing pressure on manufacturers.
Patent expiry declines revenue generated from the sales of branded drugs, and can affect the market share of a company. For instance, Flixotide/Flovent, Advair, and Serevent are major respiratory products manufactured by GlaxoSmithKline, which are now facing patent expiry. This is likely to lead to a decline in sales, thereby affecting the company’s market position. In January 2019, the FDA approved Mylan's Wixela Inhub, the first generic version of Advair Diskus for the treatment of asthma and COPD.
The availability of generic versions of medicines in the market affects the sales of branded drugs in developed regions such as North America and Europe, and causes pricing pressure, as such, restraining the growth of the chronic obstructive disease treatment market.
Global Chronic Obstructive Pulmonary Disease Market: Competition Landscape
This report profiles major players in the global COPD treatment market based on various attributes such as company overview, financial overview, product portfolio, business strategies, and recent developments
Prominent players operating in the global chronic obstructive pulmonary disease treatment market include
Key Questions Answered in the COPD Treatment Market Report
Chronic Obstructive Pulmonary Disease Treatment Market – Segmentation