Plasma Protein Therapeutics Market (Product: Immunoglobulin, Albumin, Coagulation Factor, C1-esterase inhibitors, Others), Applications (Hemophilia, Primary Immunodeficiency, Disorder (PID), Idiopathic Thrombocytopenic, Purpura, Secondary Immunodeficiency, Hereditary Angioedema, Other Indications) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2019 - 2030

The Plasma Protein Therapeutics Market for the historical period 2017–2018 and forecast period 2019–2027, Growing Investment in Innovation, Rising Demand for Immunoglobulin (IG), Rising Indications and Therapeutic use of Plasma Derived Protein Therapeutics are projected to drive the plasma protein therapeutics market

According to the report, the Plasma Protein Therapeutics Market was valued at US$ 22.41 Bn in 2018 and is projected to expand at a CAGR of 7.0% from 2019 to 2030

Growing Investment in Innovation: Key Drivers

Quality and advancements have been the success drivers of the plasma protein industry in order to increase the quality of life of patients and to guarantee donor safety. Plasma acquired via apheresis technology or complete blood donation processing can either be assembled or fractionated into plasma protein products that comprise one or more purified plasma protein or transfused directly to patients.

The plasma protein industry has been investing in research and development of new plasma proteins therapies (e.g.: Ceruloplasmin, IgA, Plasmin) leading to innovative treatments for the benefits of patients. In March 2016, Grifols announced that it will invest US$ 360 Mn to expand production capabilities for plasma-derived therapies. The investment will increase the plasma fractionation capacity and purification of several proteins.

This has been also evident from advancements such as the product presentations (e.g. subcutaneous IG, IVIG 10% concentration, and IVIG liquid presentation), manufacturing process (e.g. improvement of yield), added virus elimination technologies (e.g. nanofiltration), and development of new plasma proteins (e.g. protein C and purified factor V)

Technological advancements in efficient and cost-effective procedures for fractionating proteins from plasma are anticipated to boost the plasma protein therapeutic market. According to the World Health Organization, global blood donation come from the high income countries, i.e., more than half of the 108 million, which is the home for 18% of the world’s population.

Rising incidence of over 200 life threatening diseases affecting immune or neurological system such as chronic inflammatory demyelinating polyneuropathy (CIPD), multifocal motor neuropathy (MMN), ideopathic thrombocytopenic purpura (ITP), and other infectious diseases including hepatitis A&B, rabies, tetanus, and varicella is driving the market.

Rising Demand for Immunoglobulins (IG)

The number of clinical indications for IG has been increasing. IG has become an important treatment option in a number of clinical indications beyond primary immunodeficiency, including autoimmune and acute inflammatory conditions. Also, off-label prescribing has crossed over into almost every medical specialty. Chronic use of off-label prescribing in some indications, particularly for the treatment of some neurological illnesses, in addition to immune deficiencies is increasing demand for IG.

Plasma-derived IG is used for a wide range of autoimmune and inflammatory diseases. Increased recognition and treatment of immune deficiencies in developing world have added to the global demand for IG. However, increased use of high dose therapy, particularly in autoimmune neurologic diseases is the major reason for the continued strong growth in demand for IG products.

Widespread off-label use of IG demonstrates use of large volume of plasma. Examples of most common off-label uses for IVIG in the U.S. are multifocal motor neuropathy (MMN), acute panautonomic polyneuropathy, hemolytic disease of the newborn, autoimmune mucocutaneous blistering diseases, and acute cardiomyopathy.

The clinical demand for these medicines has increased in the past few years and the trend is likely to continue due to constant improvement in diagnosis and improved life-expectancy

Stringent Regulation and Reimbursement Issues Threat to Hamper Market

The plasma collection standards in emerging countries do not match those required by the fractionators. These regions follow strict rules and regulations regarding the quality of their operations, starting with the quality of the raw material. Specific fractionators are designed for plasma. For instance, the European health authorities require that the plasma pool for fractionation be tested for HIV, hepatitis A, B and C, and Parvovirus B. The blood collected by many centers is often unable to comply with these regulations, causing some recovered plasma to be unused.

Health budgets have been subjected to growing pressures. Funding through reimbursement pathways from private and public payers has come under inspection and it has drawn plasma protein therapies into the landscape of Health Technology Assessments (HTA), including the possible application of cost-utility analysis (CUA) in the distribution of reimbursement funds. Given the high cost of the therapies and the comparatively nascent nature of many of the indications, application of these tools of health economics can constraint the supply of products for patients in genuine need.

Regulatory and quality policies affect every step of the plasma protein therapy lifecycle, which includes donor safety, quality and compliance, biological license application process, therapy safety and efficacy, and pharmacovigilance. For example, licensing and inspecting of plasma collection centers and plasma protein therapy manufacturing facilities can be tedious and time consuming.

Plasma protein therapies used by Medicare beneficiaries predominately are reimbursed through Medicare Part B, which covers physician-administered therapies. In addition to being a complex technology, prices of raw materials and multiple safety measures contribute to the cost of these products. Hence, it is essential that reimbursement for plasma protein therapies is sufficient to maintain access.

Plasma Protein Therapeutics Market: Competitive Landscape

This report profiles major players in the plasma protein therapeutics market based on various attributes such as company overview, financial overview, product portfolio, business strategies, and recent developments

The plasma protein therapeutics market is fragmented, with the presence of a number of international as well as regional players

Various players operating in the plasma protein therapeutics market are

• Baxter International
• Biotests
• CSL Behring
• GRIFOLS, S.A
•  Kedrion
• Octapharma USA, Inc.
• Shire Plc.
• China Biologics.

Key Questions Answered in Global Plasma Protein Therapeutics Market Report

• What is the scope of growth of product companies in the Global Plasma Protein Therapeutics Market?
• What will be the Y-o-Y growth of the Global Plasma Protein Therapeutics Market between 2019 and 2027?
• What is the influence of changing trends in technologies on the Global Plasma Protein Therapeutics Market?
• Will North America continue to be the most profitable market for Plasma Protein Therapeutics providers?
• Which factors are anticipated to hamper the growth of the Global Plasma Protein Therapeutics Market during the forecast period?
• Which are the leading companies in the Global Plasma Protein Therapeutics Market?

Global Plasma Protein Therapeutics Market- Segmentation

Product

• Immunoglobulin
• Albumin
• Coagulation Factor
• C1-esterase inhibitors
• Others

Application

• Primary Immunodeficiency Disorder (PID)
• Idiopathic Thrombocytopenic Purpura
• Secondary Immunodeficiency
• Hereditary Angioedema
• Other Indications

Region

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

1. Preface

    1.1. Market Definition and Scope

    1.2. Market Segmentation

    1.3. Key Research Objectives

    1.4. Research Highlights

2. Assumptions and Research Methodology

3. Executive Summary: Global Plasma Protein Therapeutics Market

4. Market Overview

    4.1. Introduction

        4.1.1. Type Definition

        4.1.2. Industry Evolution / Developments

    4.2. Overview

    4.3. Market Dynamics

        4.3.1. Drivers

        4.3.2. Restraints

        4.3.3. Opportunities

    4.4. Global Plasma Protein Therapeutics Market Analysis and Forecast, 2017–2030

        4.4.1. Market Revenue Projections (US$ Mn)

    4.5. Porter’s Five Force Analysis

5. Key Insights

    5.1. Pipeline Analysis

    5.2. Phase 1 and Phase 2 Drugs (Qualitative Analyses)

    5.3. Phase 3 Drugs (Quantitative)

6. Global Plasma Protein Therapeutics Market Analysis and Forecast, by Product

    6.1. Introduction & Definition

        6.1.1. Key Findings / Developments

    6.2. Global Plasma Protein Therapeutics Market Value Forecast, by Product, 2017–2030

        6.2.1. Immunoglobulin 

        6.2.2. Albumin 

        6.2.3. Coagulation Factor

        6.2.4. C1-esterase inhibitors

        6.2.5. Others

    6.3. Global Plasma Protein Therapeutics Market Value Forecast, by Application, 2017–2030

        6.3.1. Hemophilia

        6.3.2. Primary Immunodeficiency Disorder (PID)

        6.3.3. Idiopathic Thrombocytopenic Purpura

        6.3.4. Secondary Immunodeficiency

        6.3.5. Hereditary Angioedema

        6.3.6. Other Indications

    6.4. Global Plasma Protein Therapeutics Market Attractiveness, by Product

    6.5. Global Plasma Protein Therapeutics Market Attractiveness, by Application

7. Global Plasma Protein Therapeutics Market Analysis and Forecast, by Region

    7.1. Key Findings

    7.2. Global Plasma Protein Therapeutics Market Value Forecast, by Region

        7.2.1. North America 

        7.2.2. Europe 

        7.2.3. Asia Pacific 

        7.2.4. Latin America 

        7.2.5. Middle East & Africa 

    7.3. Global Plasma Protein Therapeutics Market Attractiveness, by Region

8. North America Plasma Protein Therapeutics Market Analysis and Forecast

    8.1. Introduction

        8.1.1. Key Findings

    8.2. North America Plasma Protein Therapeutics Market Value Forecast, by Product, 2017–2030

        8.2.1. Immunoglobulin 

        8.2.2. Albumin 

        8.2.3. Coagulation Factor

        8.2.4. C1-esterase inhibitors

        8.2.5. Others

    8.3. North America Plasma Protein Therapeutics Market Value Forecast, by Application, 2017–2030

        8.3.1. Hemophilia

        8.3.2. Primary Immunodeficiency Disorder (PID)

        8.3.3. Idiopathic Thrombocytopenic Purpura

        8.3.4. Secondary Immunodeficiency

        8.3.5. Hereditary Angioedema

        8.3.6. Other Indications

    8.4. North America Plasma Protein Therapeutics Market Value (US$ Mn) Forecast, by Country, 2017–2030

        8.4.1. U.S.

        8.4.2. Canada

    8.5. North America Plasma Protein Therapeutics Market Attractiveness Analysis 

        8.5.1. By Product 

        8.5.2. By Application 

        8.5.3. By Country

9. Europe Plasma Protein Therapeutics Market Analysis and Forecast

    9.1. Introduction

        9.1.1. Key Findings

10. Europe Plasma Protein Therapeutics Market Analysis and Forecast

    10.1. Introduction

        10.1.1. Key Findings

    10.2. Europe Plasma Protein Therapeutics Market Value Forecast, by Product, 2017–2030

        10.2.1. Immunoglobulin 

        10.2.2. Albumin 

        10.2.3. Coagulation Factor

        10.2.4. C1-esterase inhibitors

        10.2.5. Others

    10.3. Europe Plasma Protein Therapeutics Market Value Forecast, by Application, 2017–2030

        10.3.1. Hemophilia

        10.3.2. Primary Immunodeficiency Disorder (PID)

        10.3.3. Idiopathic Thrombocytopenic Purpura

        10.3.4. Secondary Immunodeficiency

        10.3.5. Hereditary Angioedema

        10.3.6. Other Indications

    10.4. Europe Plasma Protein Therapeutics Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2030

        10.4.1. Germany

        10.4.2. U.K.

        10.4.3. France

        10.4.4. Spain

        10.4.5. Italy

        10.4.6. Rest of Europe 

    10.5. Europe Plasma Protein Therapeutics Market Attractiveness Analysis 

        10.5.1. By Product

        10.5.2. By Application 

        10.5.3. By Country/Sub-region

11. Asia Pacific Plasma Protein Therapeutics Market Analysis and Forecast

    11.1. Introduction

        11.1.1. Key Findings

    11.2. Asia Pacific Plasma Protein Therapeutics Market Value Forecast, by Product, 2017–2030

        11.2.1. Immunoglobulin 

        11.2.2. Albumin 

        11.2.3. Coagulation Factor

        11.2.4. C1-esterase inhibitors

        11.2.5. Others

    11.3. Asia Pacific Plasma Protein Therapeutics Market Value Forecast, by Application, 2017–2030

        11.3.1. Hemophilia

        11.3.2. Primary Immunodeficiency Disorder (PID)

        11.3.3. Idiopathic Thrombocytopenic Purpura

        11.3.4. Secondary Immunodeficiency

        11.3.5. Hereditary Angioedema

        11.3.6. Other Indications

    11.4. Asia Pacific Plasma Protein Therapeutics Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2030

        11.4.1. China

        11.4.2. Japan

        11.4.3. India

        11.4.4. Australia & New Zealand

        11.4.5. Rest of Asia Pacific 

    11.5. Asia Pacific Plasma Protein Therapeutics Market Attractiveness Analysis 

        11.5.1. By Product

        11.5.2. By Application 

        11.5.3. By Country/Sub-region

12. Latin America Plasma Protein Therapeutics Market Analysis and Forecast

    12.1. Introduction

        12.1.1. Key Findings

    12.2. Latin America Plasma Protein Therapeutics Market Value Forecast, by Product, 2017–2030

        12.2.1. Immunoglobulin 

        12.2.2. Albumin 

        12.2.3. Coagulation Factor

        12.2.4. C1-esterase inhibitors

        12.2.5. Others

    12.3. Latin America Plasma Protein Therapeutics Market Value Forecast, by Application, 2017–2030

        12.3.1. Hemophilia

        12.3.2. Primary Immunodeficiency Disorder (PID)

        12.3.3. Idiopathic Thrombocytopenic Purpura

        12.3.4. Secondary Immunodeficiency

        12.3.5. Hereditary Angioedema

        12.3.6. Other Indications

    12.4. Latin America Plasma Protein Therapeutics Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2030

        12.4.1. Brazil

        12.4.2. Mexico

        12.4.3. Rest of Latin America Latin America 

    12.5. Latin America Plasma Protein Therapeutics Market Attractiveness Analysis 

        12.5.1. By Product

        12.5.2. By Application 

        12.5.3. By Country/Sub-region

13. Middle East & Africa Plasma Protein Therapeutics Market Analysis and Forecast

    13.1. Introduction

        13.1.1. Key Findings

    13.2. Middle East & Africa Plasma Protein Therapeutics Market Value Forecast, by Product, 2017–2030

        13.2.1. Immunoglobulin 

        13.2.2. Albumin 

        13.2.3. Coagulation Factor

        13.2.4. C1-esterase inhibitors

        13.2.5. Others

    13.3. Middle East & Africa Plasma Protein Therapeutics Market Value Forecast, by Application, 2017–2030

        13.3.1. Hemophilia

        13.3.2. Primary Immunodeficiency Disorder (PID)

        13.3.3. Idiopathic Thrombocytopenic Purpura

        13.3.4. Secondary Immunodeficiency

        13.3.5. Hereditary Angioedema

        13.3.6. Other Indications

    13.4. Middle East & Africa Plasma Protein Therapeutics Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2030

        13.4.1. GCC Countries

        13.4.2. South Africa

        13.4.3. Rest of Middle East & Africa 

    13.5. Middle East & Africa Plasma Protein Therapeutics Market Attractiveness Analysis 

        13.5.1. By Product

        13.5.2. By Application 

        13.5.3. By Country/Sub-region

14. Competition Landscape

    14.1. Mergers & Acquisitions (M&A)

    14.2. Funding

    14.3. Company Profiles

        14.3.1. Dexcom, Inc. 

            14.3.1.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.1.2. Growth Strategies

            14.3.1.3. SWOT Analysis

        14.3.2. Apple, Inc. 

            14.3.2.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.2.2. Growth Strategies

            14.3.2.3. SWOT Analysis

        14.3.3. FitBit, Inc. 

            14.3.3.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.3.2. Growth Strategies

            14.3.3.3. SWOT Analysis

        14.3.4. Withings 

            14.3.4.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.4.2. Growth Strategies

            14.3.4.3. SWOT Analysis

        14.3.5. Proteus Digital Health

            14.3.5.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.5.2. Growth Strategies

            14.3.5.3. SWOT Analysis

        14.3.6. Omada Health, Inc. 

            14.3.6.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.6.2. Growth Strategies

            14.3.6.3. SWOT Analysis 

        14.3.7. WellDoc, Inc. 

            14.3.7.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.7.2. Growth Strategies

            14.3.7.3. SWOT Analysis

        14.3.8. Livongo Health 

            14.3.8.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.8.2. Growth Strategies

            14.3.8.3. SWOT Analysis

        14.3.9. Noom, Inc. 

            14.3.9.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.9.2. Growth Strategies

            14.3.9.3. SWOT Analysis

        14.3.10. Ginger.io, Inc. 

            14.3.10.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.10.2. Growth Strategies

            14.3.10.3. SWOT Analysis

        14.3.11. Propeller Health 

            14.3.11.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.11.2. Growth Strategies

            14.3.11.3. SWOT Analysis

        14.3.12. 2Morrow, Inc.

            14.3.12.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.12.2. Growth Strategies

            14.3.12.3. SWOT Analysis

        14.3.13. Canary Health 

            14.3.13.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.13.2. Growth Strategies

            14.3.13.3. SWOT Analysis

        14.3.14. Mango Health

            14.3.14.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.14.2. Growth Strategies

            14.3.14.3. SWOT Analysis

        14.3.15. BiogeniQ Inc.

            14.3.15.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.15.2. Growth Strategies

            14.3.15.3. SWOT Analysis

        14.3.16. Twine Health, Inc.

            14.3.16.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.16.2. Growth Strategies

            14.3.16.3. SWOT Analysis

        14.3.17. Glooko, Inc.

            14.3.17.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.17.2. Growth Strategies

            14.3.17.3. SWOT Analysis

        14.3.18. Firstbeat Technologies Ltd 

            14.3.18.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.18.2. Growth Strategies

            14.3.18.3. SWOT Analysis

        14.3.19. Claritas MindSciences

            14.3.19.1.  Company Overview (HQ, Business Segments, Employee Strength)

            14.3.19.2. Growth Strategies

            14.3.19.3. SWOT Analysis

        14.3.20. Big Health 

            14.3.20.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.20.2. Growth Strategies

            14.3.20.3. SWOT Analysis

        14.3.21. Dthera Sciences 

            14.3.21.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.21.2. Growth Strategies

            14.3.21.3. SWOT Analysis

        14.3.22. Virta Health Corp

            14.3.22.1.  Company Overview (HQ, Business Segments, Employee Strength)

            14.3.22.2. Growth Strategies

            14.3.22.3. SWOT Analysis

        14.3.23. Zest Health, LLC 

            14.3.23.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.23.2. Growth Strategies

            14.3.23.3. SWOT Analysis

        14.3.24. Meru Health, Inc.

            14.3.24.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.24.2. Growth Strategies

            14.3.24.3. SWOT Analysis

        14.3.25. HealthMine, Inc. 

            14.3.25.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.25.2. Growth Strategies

            14.3.25.3. SWOT Analysis

        14.3.26. Pear Therapeutics, Inc. 

            14.3.26.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.26.2. Growth Strategies

            14.3.26.3. SWOT Analysis

        14.3.27. BioTelemetry, Inc. 

            14.3.27.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.27.2. Growth Strategies

            14.3.27.3. SWOT Analysis

        14.3.28. Blue Mesa Health 

            14.3.28.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.28.2. Growth Strategies

            14.3.28.3. SWOT Analysis

        14.3.29. Digital Therapeutics 

            14.3.29.1. Company Overview (HQ, Business Segments, Employee Strength)

            14.3.29.2. Growth Strategies

            14.3.29.3. SWOT Analysis